Birth of parthenogenetic mice that can develop to adulthood

@article{Kono2004BirthOP,
  title={Birth of parthenogenetic mice that can develop to adulthood},
  author={T. Kono and Y. Obata and Q. Wu and K. Niwa and Yukiko Ono and Y. Yamamoto and E. S. Park and J. Seo and H. Ogawa},
  journal={Nature},
  year={2004},
  volume={428},
  pages={860-864}
}
  • T. Kono, Y. Obata, +6 authors H. Ogawa
  • Published 2004
  • Biology, Medicine
  • Nature
  • Only mammals have relinquished parthenogenesis, a means of producing descendants solely from maternal germ cells. [...] Key Method This development was made possible by the appropriate expression of the Igf2 and H19 genes with other imprinted genes, using mutant mice with a 13-kilobase deletion in the H19 gene as non-growing oocytes donors. This full-term development is associated with a marked reduction in aberrantly expressed genes. The parthenote developed to adulthood with the ability to reproduce offspring…Expand Abstract
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