Birth of parthenogenetic mice that can develop to adulthood

  title={Birth of parthenogenetic mice that can develop to adulthood},
  author={T. Kono and Y. Obata and Q. Wu and K. Niwa and Yukiko Ono and Y. Yamamoto and E. S. Park and J. Seo and H. Ogawa},
  • T. Kono, Y. Obata, +6 authors H. Ogawa
  • Published 2004
  • Biology, Medicine
  • Nature
  • Only mammals have relinquished parthenogenesis, a means of producing descendants solely from maternal germ cells. [...] Key Method This development was made possible by the appropriate expression of the Igf2 and H19 genes with other imprinted genes, using mutant mice with a 13-kilobase deletion in the H19 gene as non-growing oocytes donors. This full-term development is associated with a marked reduction in aberrantly expressed genes. The parthenote developed to adulthood with the ability to reproduce offspring…Expand Abstract
    450 Citations

    Figures and Topics from this paper.

    Genomic imprinting is a barrier to parthenogenesis in mammals
    • T. Kono
    • Medicine, Biology
    • Cytogenetic and Genome Research
    • 2006
    • 57
    Birth of Parthenote Mice Directly from Parthenogenetic Embryonic Stem Cells
    • 55
    • PDF
    Birth of mice produced by germ cell nuclear transfer
    • 50
    Functional full-term placentas formed from parthenogenetic embryos using serial nuclear transfer
    • 16
    • PDF
    Three paternally imprinted regions are sequentially required in prenatal and postnatal mouse development
    • 1
    Genetic modification for bimaternal embryo development.
    • T. Kono
    • Medicine, Biology
    • Reproduction, fertility, and development
    • 2009
    • 9
    Regulated expression of two sets of paternally imprinted genes is necessary for mouse parthenogenetic development to term.
    • 45
    • PDF
    Parthenogenetic Embryonic Stem Cells in Nonhuman Primates
    • 1


    Maternal Primary Imprinting Is Established at a Specific Time for Each Gene throughout Oocyte Growth*
    • 269
    • PDF
    Genome imprinting and development in the mouse.
    • 155
    Roles for genomic imprinting and the zygotic genome in placental development
    • 113
    • PDF
    Mechanisms of genomic imprinting.
    • K. Pfeifer
    • Medicine, Biology
    • American journal of human genetics
    • 2000
    • 157
    • PDF