Birth of a metabolic gene cluster in yeast by adaptive gene relocation

@article{Wong2005BirthOA,
  title={Birth of a metabolic gene cluster in yeast by adaptive gene relocation},
  author={Simon Wong and Kenneth H. Wolfe},
  journal={Nature Genetics},
  year={2005},
  volume={37},
  pages={777-782}
}
Although most eukaryotic genomes lack operons, they contain some physical clusters of genes that are related in function despite being unrelated in sequence. How these clusters are formed during evolution is unknown. The DAL cluster is the largest metabolic gene cluster in yeast and consists of six adjacent genes encoding proteins that enable Saccharomyces cerevisiae to use allantoin as a nitrogen source. We show here that the DAL cluster was assembled, quite recently in evolutionary terms… CONTINUE READING
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