Birth of a healthy neonate following the intracytoplasmic injection of testicular spermatozoa from a patient with Klinefelter's syndrome.

@article{Ronel1999BirthOA,
  title={Birth of a healthy neonate following the intracytoplasmic injection of testicular spermatozoa from a patient with Klinefelter's syndrome.},
  author={R Ron-el and Shevach Friedler and Deborah Strassburger and Daphna Komarovsky and Morey Schachter and Arieh Raziel},
  journal={Human reproduction},
  year={1999},
  volume={14 2},
  pages={368-70}
}
Klinefelter's syndrome is one of the known causes of azoospermia or cryptoazoospermia, and it may present in non-mosaic (47,XXY) or mosaic (47,XXY/46,XY) form. The likelihood of finding spermatozoa in the ejaculate or testicular tissue of patients with mosaic Klinefelter's syndrome is low, and with the non-mosaic form, even lower. We describe a patient with non-mosaic Klinefelter in whom initially non-motile spermatozoa were derived from searching the ejaculate. Ten mature oocytes were injected… CONTINUE READING

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