Birch pollen immunotherapy results in long-term loss of Bet v 1-specific TH2 responses, transient TR1 activation, and synthesis of IgE-blocking antibodies.

@article{Mbs2012BirchPI,
  title={Birch pollen immunotherapy results in long-term loss of Bet v 1-specific TH2 responses, transient TR1 activation, and synthesis of IgE-blocking antibodies.},
  author={Christian M{\"o}bs and Henrik Ipsen and Lea Mayer and Caroline M Slotosch and Arnd Petersen and Peter Adler W{\"u}rtzen and Michael Hertl and Wolfgang Pf{\"u}tzner},
  journal={The Journal of allergy and clinical immunology},
  year={2012},
  volume={130 5},
  pages={1108-1116.e6}
}
BACKGROUND Early events of specific immunotherapy (SIT) are induction of allergen-specific IL-10-producing T(R)1 cells and production of IgG antibodies, but there is little knowledge about the long-term immune mechanisms responsible for sustained allergen tolerance. OBJECTIVE Bet v 1-specific immune responses of 16 patients with birch pollen allergy were characterized up to 54 months at defined time points before, during, and after a 3-year period of SIT. METHODS We sought to analyze… CONTINUE READING

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