Bipolar disorders

  title={Bipolar disorders},
  author={Roger S. McIntyre and Michael Berk and Elisa Brietzke and Benjamin I. Goldstein and Carlos L{\'o}pez-Jaramillo and Lars Vedel Kessing and Gin S. Malhi and Andrew A. Nierenberg and Joshua D. Rosenblat and Amna Majeed and Eduard Vieta and Maj Vinberg and Allan H. Young and Rodrigo B. Mansur},
  journal={The Lancet},

COVID-19-Related Mortality Risk in People With Severe Mental Illness: A Systematic and Critical Review

Evidence suggests that SMI is associated with excess COVID-19-related mortality, as compared to patients without SMI, and policy makers must consider these vulnerable individuals as a high-risk group that should be given particular attention.

The importance of countertransference in the clinical care of individuals during acute phases of bipolar disorder

Bipolar Disorder optimal care involves pharmacotherapy in conjunction with psychosocial interventions, a cornerstone for the successful treatment of any chronic illness regardless of the psychotherapeutic model.

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder.

Only ketamine appeared to be more efficacious than placebo 24 hours after infusion for response rate and depression rating scale scores, and the acceptability of ketamine and other glutamate receptor modulators in people with bipolar disorder was reviewed.

Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System

Whether D2/D3 partial agonists/antagonists acting on D2 and D3 receptors bear the promise of a future therapeutic approach especially in patients with comorbid BD and SUD is examined.

Depressive and Anxious Temperaments as Predictors of Late Onset Bipolar Disorder? Preliminary Results of a “Real World” Exploratory Study

Introduction Bipolar disorder (BD) onset typically occurs between 15 and 30 years, being diagnosed under the age of 50 in 90% of cases, named “non-late onset BD” (non-LOBD). However, clinical

Bipolar Disorder and Athletes: A Narrative Review

The aim of this review is to summarize the available evidence and to highlight relevant risk factors, diagnostic features, management, and potential complications pertaining to the athletic population.



Bipolar disorder

The genetics of bipolar disorder

Bipolar depression: the clinical characteristics and unmet needs of a complex disorder

Clinicians should be alert for symptoms of bipolar disorder in undiagnosed patients, know what symptoms probabilistically suggest bipolar versus unipolar depression, have expertise in providing ongoing treatment to diagnosed patients, and be knowledgeable about managing common medication-related side effects and comorbidities.

Medical burden in bipolar disorder: findings from the Clinical and Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder study (Bipolar CHOICE).

There appears to be a substantial medical burden associated with bipolar disorder, highlighting the need for collaborative care among psychiatric and general medical providers to address both psychiatric and other medical needs concomitantly in this group of patients.

Association between antidepressant resistance in unipolar depression and subsequent bipolar disorder: cohort study

The first large-scale study to report an association between antidepressant response history and subsequent change in diagnosis from major depressive disorder to bipolar disorder is reported, indicating that a history of poor response to antidepressants in unipolar depression could be a useful predictor for bipolar diathesis.

Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta‐analysis

The data suggest that the risk for MetS is similarly elevated in the diagnostic subgroups of severe mental illness, and routine screening and multidisciplinary management of medical and behavioral conditions is needed in these patients.

Comorbidity in bipolar disorder: a framework for rational treatment selection

Clinicians are encouraged to invoke an organizational schema for the treatment of bipolar disorder that considers the spectrum of effectiveness of putative and established mood stabilizers, and should be further informed by the treatment data for comorbid and accessory conditions.

Prevalence of smoking in patients with bipolar disorder, major depressive disorder and schizophrenia and their relationships with quality of life

Male gender, living alone, higher personal income, older age of onset, health insurance coverage, and first episode was significantly associated with smoking in one or more diagnostic groups, while no difference was found between bipolar disorder and schizophrenia.

Impact of childhood abuse on the clinical course of bipolar disorder

Severe childhood trauma appears to have occurred in about half of patients with bipolar disorder, and may lead to more complex psychopathological manifestations.