Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8

  title={Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8},
  author={Susan L. McElroy and Stacey J. Winham and Alfredo B. Cuellar-Barboza and Colin L. Colby and Ada Man-Choi Ho and Hugues Sicotte and Beth R. Larrabee and Scott J. Crow and Mark A. Frye and Joanna M. Biernacka},
  journal={Translational Psychiatry},
Bipolar disorder (BD) is associated with binge eating behavior (BE), and both conditions are heritable. Previously, using data from the Genetic Association Information Network (GAIN) study of BD, we performed genome-wide association (GWA) analyses of BD with BE comorbidity. Here, utilizing data from the Mayo Clinic BD Biobank (969 BD cases, 777 controls), we performed a GWA analysis of a BD subtype defined by BE, and case-only analysis comparing BD subjects with and without BE. We then… 

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