Bipolar disorder

  title={Bipolar disorder},
  author={Ian M. Anderson and Peter M. Haddad and Jan Scott},
  journal={BMJ : British Medical Journal},
Bipolar (affective) disorder, originally called manic depressive illness, is one of the most challenging psychiatric disorders to manage. Although it has been associated with creativity, it has a negative impact on the lives of most patients and more than 6% die through suicide in the two decades after diagnosis. Organisational change means that specialist services mostly treat acute episodes, leaving primary care with long term management. This review summarises current best practice in the… 

Adult ADHD in Bipolar and Related Disorders

Bipolar Disorder was the fifth leading cause of DALYs in 2013, accounting for the 5.7% of the burden due to mental disorders and substance use disorders.

Genetic Advance in Depressive Disorder.

The candidate genes for MDD and BD, genetic variation loci, chromosome structural variation, new technologies, and new methods are reviewed.

Obsessive-compulsive Disorder with Comorbid Bipolar Disorders: Clinical Features and Treatment Implications.

BD-OCD comorbidity needs further investigations in order to provide more solid evidences to give patients a more precise clinical diagnosis and a more targeted therapeutic approach.


Psychiatric social work interventions have been a key area in the management of BPAD involving the family, which helps in maintaining a prolonged euthymic period and better treatment compliance.

Factors Associated with Non-Remission in Bipolar Disorder: The Multicenter Treatment Survey for Bipolar Disorder in Psychiatric Outpatient Clinics (MUSUBI)

Logistic regression analyses found the following eight factors to be significantly correlated with non-remission in patients with bipolar disorder: female gender, younger age, unemployed status, rapid cycling pattern, comorbid alcohol/substance abuse, poorer social function, lithium non-use, and antidepressant use.

Demographic and Clinical Differences Between Bipolar Disorder Patients With and Without Alcohol Use Disorders

Male, younger current age, and having other substance use disorders were independently associated with AUD.

Evaluation of Oxidative Stress in Bipolar Disorder in terms of Total Oxidant Status, Total Antioxidant Status, and Oxidative Stress Index.

No statistically significant difference was detected between the oxidative parameters of bipolar disorder patients and HCs and further studies are needed in order to comprehensively evaluate oxidative stress in bipolar disorder.

Brain gyrification in bipolar disorder: a systematic review of neuroimaging studies

An altered brain gyrification pattern that underlies the pathophysiology of BD spanning large anatomical and functional neural networks is supported, associated with altered cognitive functioning, difficulties in processing and affective regulation, and clinical symptoms.



Bipolar disorder: from genes to behavior pathways.

This article draws from neuroimaging findings in humans, postmortem data, and human genetic and pharmacological studies as well as data from animal models of behavior to discuss the neurobiology of BPD.

Insight in Bipolar Disorder

  • K. Latalova
  • Psychology, Medicine
    Psychiatric Quarterly
  • 2011
Impairments of executive functions and memory, as well as higher severity of psychotic symptoms, are associated with impairments of insight, and there is a need for integration of quantitative assessment methods and their introduction into research and clinical practice.

Depressive and manic symptoms are not opposite poles in bipolar disorder

Depressive and manic symptoms are not opposite poles in bipolar disorder.

Early Detection and Intervention in Bipolar Affective Disorder: Targeting the Development of the Disorder

Recent evidence on the characteristics of the prodrome to bipolar affective disorder is summarized and the potential value and challenges of early detection and intervention in BD are discussed.

Genetics of bipolar disorder.

Is There a Continuity between Bipolar and Depressive Disorders?

  • F. Benazzi
  • Psychology
    Psychotherapy and Psychosomatics
  • 2007
Focusing on mood spectrum’s extremes (BP-I vs. MDD), a categorical distinction seems supported and on midway disorders ( BP-II and MDD plus bipolar signs), a continuity/spectrum seems supported.

Efficacy of electroconvulsive therapy in bipolar versus unipolar major depression: a meta‐analysis

Electroconvulsive therapy in bipolar versus unipolar major depression: a meta‐analysis suggests that electroconvulsive treatment is more effective in bipolar patients than in patients with other psychiatric conditions.

Genetic architectures of psychiatric disorders: the emerging picture and its implications

Empirical approaches have yielded new hypotheses about aetiology and now provide data on the often debated genetic architectures of these conditions, which have implications for future research strategies.

The HCL-32: towards a self-assessment tool for hypomanic symptoms in outpatients.