Bipolar disorder

@article{Anderson2012BipolarD,
  title={Bipolar disorder},
  author={Ian M. Anderson and Peter M. Haddad and Jan Scott},
  journal={BMJ : British Medical Journal},
  year={2012},
  volume={345}
}
Bipolar (affective) disorder, originally called manic depressive illness, is one of the most challenging psychiatric disorders to manage. Although it has been associated with creativity, it has a negative impact on the lives of most patients and more than 6% die through suicide in the two decades after diagnosis. Organisational change means that specialist services mostly treat acute episodes, leaving primary care with long term management. This review summarises current best practice in the… 
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TLDR
The candidate genes for MDD and BD, genetic variation loci, chromosome structural variation, new technologies, and new methods are reviewed.
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TLDR
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Factors Associated with Non-Remission in Bipolar Disorder: The Multicenter Treatment Survey for Bipolar Disorder in Psychiatric Outpatient Clinics (MUSUBI)
TLDR
Logistic regression analyses found the following eight factors to be significantly correlated with non-remission in patients with bipolar disorder: female gender, younger age, unemployed status, rapid cycling pattern, comorbid alcohol/substance abuse, poorer social function, lithium non-use, and antidepressant use.
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TLDR
A unidimensional rather than categorical approach to severity of anxiety might be both useful and feasible in this population of patients with a bipolar disorder.
Demographic and Clinical Differences Between Bipolar Disorder Patients With and Without Alcohol Use Disorders
TLDR
Male, younger current age, and having other substance use disorders were independently associated with AUD.
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TLDR
Horace Wells was a Hartford, Connecticut, dentist whose practice flourished because of his clinical skills but his introduction of nitrous oxide as an anesthetic was also associated with self-inhalation, which led to periods of hypomania, followed by depression.
A genetic window to auditory-verbal problems in bipolar disorder
TLDR
It is shown that candidates for bipolar disorder significantly overlap with candidates for clinical conditions resulting from a deficit in the phonological loop of working memory, particularly, developmental dyslexia and specific language impairment.
Evaluation of Oxidative Stress in Bipolar Disorder in terms of Total Oxidant Status, Total Antioxidant Status, and Oxidative Stress Index.
TLDR
No statistically significant difference was detected between the oxidative parameters of bipolar disorder patients and HCs and further studies are needed in order to comprehensively evaluate oxidative stress in bipolar disorder.
A brief psychoeducation intervention for patients with bipolar disorder : effect on attitudes and beliefs and their relationship to clinical outcomes
Manchester University, Kirsten Bond, Doctorate of Philosophy. September 2013.A Brief Group Psychoeducation (PE) Intervention for Patients with Bipolar Disorder.Bipolar disorder (BPD) is associated
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References

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TLDR
This article draws from neuroimaging findings in humans, postmortem data, and human genetic and pharmacological studies as well as data from animal models of behavior to discuss the neurobiology of BPD.
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TLDR
Depressive and manic symptoms are not opposite poles in bipolar disorder.
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TLDR
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TLDR
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TLDR
Clinicians treating MDD are urged to search for "soft" signs of bipolarity and to be prepared to alter diagnosis and treatment strategies accordingly, to provide at least moderate support to the hypothesis that BD is a contributor to apparent TRD.
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