Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers.

@article{Manji2001BipolarDL,
  title={Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers.},
  author={Husseini K. Manji and Gregory J. Moore and Guang Chen},
  journal={The British journal of psychiatry. Supplement},
  year={2001},
  volume={41},
  pages={s107-19}
}
BACKGROUND New research is dramatically altering our understanding of the molecular mechanisms underlying neuronal communication. AIM To elucidate the molecular mechanisms underlying the therapeutic effects of mood stabilizers. METHOD Results from integrated clinical and laboratory studies are reviewed. RESULTS Chronic administration of lithium and valproate produced a striking reduction in protein kinase C (PKC) isozymes in rat frontal cortex and hippocampus. In a small study, tamoxifen… CONTINUE READING
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