• Corpus ID: 249569323

Bipolar Disorders and Lithium: Pharmacokinetics, Pharmacodynamics, Therapeutic Effects and Indications of Lithium: Review of Articles

  title={Bipolar Disorders and Lithium: Pharmacokinetics, Pharmacodynamics, Therapeutic Effects and Indications of Lithium: Review of Articles},
  • Published 2016
  • Medicine
Lithium is a mood stabilizer which is approved for use in acute and maintenance mania. It is the first medications approved for the treatment of bipolar disorders. The drug has narrow therapeutic index 0.6-1.2meq/l. The specific mechanism of action of lithium in stabilizing mood is unknown. Alters sodium transport across cell membranes in nerve and muscle cells, It alters metabolism of neurotransmitters including catecholamines and serotonin. May alter intracellular signaling through actions on… 

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Potential Mechanisms of Action of Lithium in Bipolar Disorder
It is clear that the processes which underpin the therapeutic actions of lithium are sophisticated and most likely inter-related.
Lithium and the brain: a psychopharmacological strategy to a molecular basis for manic depressive illness.
It is found that chronic, but not acute, administration of lithium in rats markedly reduces a major phosphoprotein substrate of protein kinase C in the hippocampus, an effect that persists beyond the cessation of lithium treatment.
Management of Lithium Toxicity
Enhanced elimination should be considered in patients at greatest risk of severe poisoning, namely those with chronic or acute-on-therapeutic toxicity, those with clinically significant features, and those with Chronic toxicity whose serum lithium concentration is >2.5 mmol/L.
Lithium and angiotensin-converting enzyme inhibitors: evaluation of a potential interaction.
A clinically important increase in lithium concentrations can occur in patients started on ACE inhibitor therapy, as elderly patients may be uniquely predisposed to this interaction, and avoidance of this medication combination in older populations should be considered.
The science and practice of lithium therapy
Lithium is a safe and effective agent that should be used first-line for the treatment of bipolar disorder and a better understanding of its science alongside strategic management of its plasma levels will ensure both wider utility and improved outcomes.