Bipolar Disorder and Cognitive Dysfunction: A Complex Link

@article{Cipriani2017BipolarDA,
  title={Bipolar Disorder and Cognitive Dysfunction: A Complex Link},
  author={Gabriele Cipriani and S. Danti and C. Carlesi and D. Cammisuli and M. Di Fiorino},
  journal={The Journal of Nervous and Mental Disease},
  year={2017},
  volume={205},
  pages={743–756}
}
Abstract The aim of this article was to describe the current evidence regarding phenomenon of cognitive functioning and dementia in bipolar disorder (BD). Cochrane Library and PubMed searches were conducted for relevant articles, chapters, and books published before 2016. Search terms used included “bipolar disorder,” “cognitive dysfunction,” and “dementia.” At the end of the selection process, 159 studies were included in our qualitative synthesis. As result, cognitive impairments in BD have… Expand
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References

SHOWING 1-10 OF 164 REFERENCES
Bipolar Disorder: Clinical Perspectives and Implications with Cognitive Dysfunction and Dementia
TLDR
A nonsystematic review of all English language PubMed articles published between 1995 and 2011 using the terms “bipolar disorder,” “cognitive dysfunction” and “dementia” to stand out the connection and clinical implications between cognitive dysfunction, dementia, and BPD. Expand
Bipolar disorder and dementia: where is the link?
TLDR
Questions remain concerning the appearance of dementia symptoms over the course of bipolar disorder in certain patients, and clinical, neuropsychological and cerebral imaging data are inconclusive, but similarities with frontotemporal dementia might be highlighted. Expand
Neuropsychology of bipolar disorder: a review.
TLDR
The profile of cognitive deficits in BD at different phases of the illness is described to determine whether it is different from that of schizophrenia and unipolar (UP) depression. Expand
[Dementia following bipolar disorder].
TLDR
The data of this study support a possible specific dementia postbipolar disorder and not only mild cognitive decline and such dementia could be a main differential diagnosis from long lasting frontotemporal dementia. Expand
Identifying and treating cognitive impairment in bipolar disorder.
TLDR
No current pharmacotherapies substantially improve cognition in bipolar disorder, although preliminary findings suggest some potential value for adjunctive stimulants such as modafinil and novel experimental agents. Expand
Neurocognitive functioning in the premorbid stage and in the first episode of bipolar disorder: A systematic review
TLDR
Preliminary evidence suggests that deficits in specific cognitive domains might precede the onset of illness and general intelligence is not impaired in the premorbid stage. Expand
A case series on the hypothesized connection between dementia and bipolar spectrum disorders: bipolar type VI?
TLDR
Patients with cognitive decline and frequent mood lability might be manifesting a late-onset bipolar spectrum disorder, which is posited as type VI, and dementia and/or other biopsychosocial challenges associated with aging might release latent bipolarity in such individuals. Expand
Cognitive impairment in bipolar disorder: Neurodevelopment or neurodegeneration? An ECNP expert meeting report
TLDR
Neurocognitive impairment in bipolar disorder should be considered a potential therapeutic target, so that research should focus on new drugs and psychological interventions addressed to improve not only the cognition but also the functional outcome of this population. Expand
Assessing cognitive function in bipolar disorder: challenges and recommendations for clinical trial design.
TLDR
Clinical trials to address cognitive deficits in bipolar disorder face distinctive design challenges, and it will be important to incorporate distinctive design modifications to adequately address these challenges and increase the likelihood of demonstrating cognitive remediation effects. Expand
Neurocognition in bipolar disorders--a closer look at comorbidities and medications.
TLDR
An overview of selected aspects of neurocognition in bipolar disorder with a focus on the relative contributions of medications as well as medical and psychiatric comorbid conditions to cognitive dysfunction is provided. Expand
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