Biphosphonates for the therapy of complex regional pain syndrome I – Systematic review

@article{Brunner2009BiphosphonatesFT,
  title={Biphosphonates for the therapy of complex regional pain syndrome I – Systematic review},
  author={Florian Brunner and Annina B. Schmid and Rudolf O. Kissling and Ulrike Held and Lucas M. Bachmann},
  journal={European Journal of Pain},
  year={2009},
  volume={13}
}
Therapy: Bisphosphonates for early complex regional pain syndrome
Neridronate, an aminobisphosphonate, has shown promise in reducing the often extreme and intransigent pain of complex regional pain syndrome. Welcomed clinically, what can this finding tell us about
[Complex regional pain syndrome: A current review].
TLDR
Complex regional pain syndrome (CRPS) may develop following fractures, limb trauma, or lesions of the peripheral or central nervous system and includes autonomic, sensory, and motor dysfunction.
Bisphosphonates for early complex regional pain syndrome
TLDR
Findings of a placebo-controlled trial reported by Varenna et al.,2 that the aminobisphosphonate neridronate shows significant benefits in patients with CRPS, are therefore important to clinicians dealing with this disorder.
Intravenous Therapies for Complex Regional Pain Syndrome: A Systematic Review
TLDR
There is evidence to support the use of IV bisphosphonates, immunoglobulin, ketamine, or lidocaine as valuable interventions in selected patients with CRPS, however, high-quality studies are required to further evaluate the safety, efficacy, and cost-effectiveness of IV therapies for CRPS.
Pharmacology of bisphosphonates in pain
  • T. Tzschentke
  • Biology, Medicine
    British journal of pharmacology
  • 2019
TLDR
An overview of preclinical and clinical studies of bisphosphonates in pain and discusses various pharmacological mechanisms that have been postulated to explain their analgesic effects are provided.
European Pain Management Discussion Forum
  • E. Eisenberg
  • Medicine
    Journal of pain & palliative care pharmacotherapy
  • 2007
ABSTRACT Queries from European physicians about analgesic pharmacotherapy and responses from the author are presented. Topics addressed in this issue are opioid dose conversions, bisphosphonates in
Efficacy of intramuscular clodronate in Complex Regional Pain Syndrome type I: description of a case located in the astragalus in a patient with psoriatic arthritis.
TLDR
This case report describes a case of CRPS I in the astragalus of a patient with psoriatic arthritis, successfully treated with intramuscular clodronate.
Effect of Immunomodulating Medications in Complex Regional Pain Syndrome: A Systematic Review
TLDR
Theoretically, the use of immunomodulating medication could counteract the ongoing inflammation and might be an important step in improving a disabled hand or foot, leading to further recovery, however, more high-quality intervention studies are needed.
Hypnotherapy for complex regional pain syndrome
TLDR
This case study illustrates the safe, cost-effective addition and efficacious use of hypnosis in the integrative treatment plan for a teenager with CRPS.
...
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The latest scientific findings show that the previously called reflex sympathetic dystrophy, which was supposed to be a result of a hyperreactive autonomic nervous system, is a very complex syndrome that occurs on different integration levels of the nervous system.
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