Biphenylacetic acid enhances the antagonistic action of fluoroquinolones on the GABA(A)-mediated responses of the isolated guinea-pig ileum.

@article{KoutsovitiPapadopoulou2001BiphenylaceticAE,
  title={Biphenylacetic acid enhances the antagonistic action of fluoroquinolones on the GABA(A)-mediated responses of the isolated guinea-pig ileum.},
  author={Maria Koutsoviti-Papadopoulou and Efstathios Nikolaidis and Georgios Kounenis},
  journal={Pharmacological research},
  year={2001},
  volume={44 3},
  pages={
          229-33
        }
}
This paper examines the effect of biphenylacetic acid on the antagonistic action of norfloxacin and enoxacin on the GABA(A)-mediated responses of the isolated guinea-pig ileum. GABA produced transient contractions followed by relaxation. The contractile effect of exogenously applied GABA was concentration-dependent with EC(50)= 9.8 x 10(-6) M. This contractile effect was not significantly modified by biphenylacetic acid, and the EC(50) value for GABA in the presence of 10(-5) M biphenylacetic… Expand
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References

SHOWING 1-10 OF 28 REFERENCES
Inhibitory effect of flumequine, enoxacin and norfloxacin on the GABA-induced contractile effect on the guinea pig ileum.
TLDR
The results suggest that the above fluoroquinolones tested dose-dependently inhibit the contractile effect of GABA on the guinea pig ileum and this inhibition seems to be associated with an antagonistic action of the fluoroquolones at GABAA-receptors present in the gu Guinea pig ilesum. Expand
A patch clamp study of the effects of ciprofloxacin and biphenyl acetic acid on rat hippocampal neurone GABAA and lonotropic glutamate receptors
TLDR
The data suggest that the proconvulsant effects of quinolones when combined with BPAA may be related to antagonism of central GABAA receptors but not to an interaction at ionotropic glutamate receptors. Expand
Selective antagonism of the GABAA receptor by ciprofloxacin and biphenylacetic acid
TLDR
The data indicate that ciprofloxacin and BPAA are selective antagonists of GABAA receptors, an action that may contribute to their excitatory effects in vivo and suggest that the molecular properties of GabAA receptors in different regions of the CNS influence the extent to which these drugs synergistically inhibit the GAB AA receptor. Expand
Inhibition of GABAA Receptor Chloride Channel by Quinolones and Norfloxacin-Biphenylacetic Acid Hybrid Compounds
TLDR
The results suggest that quinolones in combination with BPAA bind to GABAA receptors, thus inhibiting Cl- channel activity, and that the inhibitory potency of qu inolones may be enhanced by an intermolecular interaction withBPAA. Expand
The effects of quinolones and NSAIDs upon GABA-evoked currents recorded from rat dorsal root ganglion neurones.
TLDR
The present results support earlier binding studies and extend them by demonstrating electrophysiologically a potent quinolone/NSAID drug interaction at the GABAA receptor, commensurate with clinical observations of an increased risk of fits in patients prescribed certain quinols together with certain NSAIDs. Expand
Quinolones and fenbufen interact with GABAA receptor in dissociated hippocampal cells of rat.
TLDR
It was concluded that, in the presence of an anti-inflammatory agent, the quinolone antibiotics decrease the affinity of GABAA receptors, the result being induction of epileptogenic neurotoxicities. Expand
Inhibitory effects of quinolone antibacterial agents on gamma-aminobutyric acid binding to receptor sites in rat brain membranes
TLDR
The findings suggest that the inhibition of GABA binding to receptors (including uptake sites) in the brain may be involved in the induction of epileptogenic neurotoxicities by quinolones. Expand
Evidence that a Hybrid Molecule of Norfloxacin and Biphenylacetic Acid is a Potent Antagonist at the GABAA Receptor
TLDR
Results suggest that NFLX and BPA interact with the GABAA receptor at nearby sites and thus suppress the GABA response, which is reported to elicit serious convulsions in humans. Expand
Possible intermolecular interaction between quinolones and biphenylacetic acid inhibits gamma-aminobutyric acid receptor sites.
TLDR
The results suggest the possibility that quinolones and BPAA interact with the GABA receptor at nearby sites and that the binding affinity of qu inolones to the GABA receptors is largely enhanced by the intermolecular interaction with BPAA. Expand
Effects of quinolone carboxylic acid derivatives on GABAA receptor-mediated stimulation of gastric acid secretion and intestinal motility.
TLDR
Results suggest that the quinolone derivatives tested act as antagonists at both central and peripheral GABAA receptors, and might represent a simple and reliable method to assay the GabAA receptor antagonist properties of new quinolinone derivatives. Expand
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