Biphasic time-course of capsaicin-induced substance P depletion: failure to correlate with thermal analgesia in the rat.

Abstract

Capsaicin (15 or 100 mg/kg, s.c.) produced thermal analgesia in the rat hot plate test (55 degrees C). Capsaicin (100 mg/kg) also caused a reduction in spinal cord substance P levels. However, the time-course of capsaicin-induced depletion of substance P levels does not correlate with the time-course of thermal analgesia. Also, substance P depletion is… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Slides referencing similar topics