Biphasic regulation of plasminogen activator/inhibitor by LDL in mesangial cells.

@article{Song2002BiphasicRO,
  title={Biphasic regulation of plasminogen activator/inhibitor by LDL in mesangial cells.},
  author={Chi Young Song and Bong Cho Kim and Hye Kyoung Hong and Byoung Kwon Kim and Young Han Kim and Hyun Soon Lee},
  journal={American journal of physiology. Renal physiology},
  year={2002},
  volume={283 3},
  pages={F423-30}
}
Lipid abnormalities and dysregulation of the plasminogen activator (PA)/plasmin system may be involved in the development of glomerulosclerosis. We investigated the effects of low-density lipoprotein (LDL) on PA inhibitor-1 (PAI-1), urokinase-type PA (uPA), and tissue-type PA (tPA) in relationship to protein kinase C (PKC) in cultured human mesangial cells (HMC). LDL (200 microg/ml) induced two peaks of PKC activation at hours 0.25 and 6, with translocation of PKC-alpha, -beta(1), and -delta… CONTINUE READING