Biphasic regulation of autophagy by miR-96 in prostate cancer cells under hypoxia

@inproceedings{Ma2014BiphasicRO,
  title={Biphasic regulation of autophagy by miR-96 in prostate cancer cells under hypoxia},
  author={Yi Ma and Hao-zheng Yang and Bai-jun Dong and Han-Bing Zou and Yan Zhou and Xian-Ming Kong and Yiran Huang},
  booktitle={Oncotarget},
  year={2014}
}
Autophagy favors cell survival under hypoxia, and increasing evidence revealed that microRNAs regulate autophagy. We report here hypoxia increased the expression of miR-96 in prostate cancer cells, and miR-96 stimulated autophagy by suppressing MTOR. We found that inhibition of miR-96 abolished hypoxia-induced autophagy. Paradoxically, ectopic over-expression of miR-96 to a certain threshold, also abolished the hypoxia-induced autophagy. Further studies have shown that high levels of miR-96… CONTINUE READING
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