Biphasic increasing effect of angiotensin-II on intracellular free calcium in isolated rat early proximal tubule.

@article{Jung1989BiphasicIE,
  title={Biphasic increasing effect of angiotensin-II on intracellular free calcium in isolated rat early proximal tubule.},
  author={Kyu Yong Jung and Hitoshi Endou},
  journal={Biochemical and biophysical research communications},
  year={1989},
  volume={165 3},
  pages={1221-8}
}
In the freshly isolated early proximal tubule (S1), the effect of angiotensin II (ANG II) on cytosolic Ca++ concentration ([Ca++]i) was determined using the fluorescent indicator fura-2. In order to establish an adequate experimental system, we investigated firstly the relationship between cellular ATP and [Ca++]i under various conditions in late proximal tubule, the most fragile nephron segment, and cortical collecting tubule, a relatively stable one. We found out that cellular ATP depletion… CONTINUE READING