Biphasic electric current stimulates proliferation and induces VEGF production in osteoblasts.

@article{Kim2006BiphasicEC,
  title={Biphasic electric current stimulates proliferation and induces VEGF production in osteoblasts.},
  author={I. Kim and J. Song and Y. Zhang and T. Lee and T. Cho and Y. M. Song and Do Kyun Kim and S. Kim and S. Hwang},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1763 9},
  pages={
          907-16
        }
}
This study investigated biphasic electric current (BEC) functions as a new type of electrical stimulation to induce rat calvarial osteoblasts to proliferate, differentiate and synthesize cytokines. The culture system was designed so that biphasic current flowed between upper and lower gold plates. BEC helps to minimize the net charge accumulation during cell exposure to the electrical stimulation. Osteoblasts were exposed to electrical stimulation of 1.5 microA/cm2 at 3000 Hz, and the effect of… Expand
Novel effect of biphasic electric current on in vitro osteogenesis and cytokine production in human mesenchymal stromal cells.
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Findings reveal that BEC is involved in the osteoblast differentiation of hMSCs through enhancement of cell proliferation and modulation of the local endocrine environment through VEGF and BMP-2 induction through the activation of MAPK and p38 and the calcium channel. Expand
Direct electrical stimulation enhances osteogenesis by inducing Bmp2 and Spp1 expressions from macrophages and preosteoblasts
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It is shown that macrophages could respond to ES and potentially contribute to the bone formation alongside preosteoblasts and the upregulation of Bmp2 and Spp1 expressions induced by ES could be one of the mechanisms behind the electrically stimulated osteogenesis. Expand
Modulation of Osteogenesis in MC3T3-E1 Cells by Different Frequency Electrical Stimulation
TLDR
Results indicate that 100Hz ES exhibits superior potentialities in osteogenesis, which should be beneficial for the clinical applications of ES for the treatment of bone diseases. Expand
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TLDR
The results demonstrated that only a suitable daily stimulation time supported to obviously upregulate the expression of ALP protein and osteogenesis-related genes (ALP, Col-I, Runx2 and OCN), while a short or long daily stimulationTime showed no significant outcomes. Expand
Continuous Electrical Stimulation Affects Initial Growth and Proliferation of Adipose-Derived Stem Cells
TLDR
Continuous electrical stimulation of human adipose-derived stem cells led to a significantly increased cell growth and proliferation after 3 days, however, longer stimulation periods such as 7 days caused an opposite result indicating initiation of apoptosis. Expand
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TLDR
Electrical stimulation is a useful tool to improve hMSC osteogenic differentiation, while heat shock proteins may reveal underlying mechanisms, and optical non-invasive imaging may be used to monitor the induced morphological and biochemical changes. Expand
Effects of Micro-Electrical Stimulation on Regulation of Behavior of Electro-Active Stem Cells
TLDR
The findings indicate that mES may induce DPSC proliferation and differentiation, resulting in applying to DPSCs-based human or animal tissue regeneration. Expand
Magnetically induced electrostimulation of human osteoblasts results in enhanced cell viability and osteogenic differentiation
TLDR
It is demonstrated that stimulation with electromagnetic fields and an additional alternating electric field has a positive influence on hOBs as regards cell viability and the expression of osteoblastic differentiation markers. Expand
Low current electrical stimulation upregulates cytokine expression in the anal sphincter
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Electrical stimulation for 1 h significantly upregulates SDF-1 and MCP-3 expression that persists for 24 h and reduced chemokine expression, suggesting electrolysis of cells. Expand
Electrical Stimulation of Titanium to Promote Stem Cell Orientation, Elongation and Osteogenesis.
Electrical stimulation of cells allows exogenous electric signals as stimuli to manipulate cell growth, preferential orientation and bone remodelling. In this study, commercially pure titanium discsExpand
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