Biphasic effects of zonisamide on serotonergic system in rat hippocampus

@article{Okada1999BiphasicEO,
  title={Biphasic effects of zonisamide on serotonergic system in rat hippocampus},
  author={Motohiro Okada and Takayuki Hirano and Yuko Kawata and Takuya Murakami and Sunao Kaneko},
  journal={Epilepsy Research},
  year={1999},
  volume={34},
  pages={187-197}
}
To study the mechanisms of antiepileptic action of zonisamide (ZNS), we determined the effects of ZNS on extracellular, total levels and re-uptake activity of serotonin (5-HT) in rat striatum and hippocampus. After acute administrations, plasma ZNS concentrations associated with anticonvulsive action (effective concentrations) increased the total levels of 5-HT, its metabolise (5-hydroxyindoleacetic acid: 5-HIAA) and precursor (5-hydroxytryptophan: 5-HTP). After chronic administration of ZNS… CONTINUE READING
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