Biphasic effects of morphine on bulbar respiratory neuronal activities in decerebrate cats.

@article{Haji2003BiphasicEO,
  title={Biphasic effects of morphine on bulbar respiratory neuronal activities in decerebrate cats.},
  author={Akira Haji and Mari Okazaki and Yoshiaki Ohi and Hiromi Yamazaki and Ryuji Takeda},
  journal={Neuropharmacology},
  year={2003},
  volume={45 3},
  pages={368-79}
}
To understand neuronal mechanisms underlying respiratory depression induced by morphine, membrane potential, input resistance and burst discharge in different types of respiratory neurons were recorded in decerebrate and vagotomized cats. Intravenous morphine (0.3-3.0 mg/kg) dose-dependently decreased the respiratory discharge in the phrenic and iliohypogastric nerves. The drug changed the respiratory frequency in a biphasic fashion, a transient increase (early phase) followed by a long-lasting… CONTINUE READING