Biphasic effects of epidermal growth factor on bone nodule formation by isolated rat calvaria cells in vitro.

@article{Antosz1987BiphasicEO,
  title={Biphasic effects of epidermal growth factor on bone nodule formation by isolated rat calvaria cells in vitro.},
  author={M. E. Antosz and Carlton G Bellows and Jane E. Aubin},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1987},
  volume={2 5},
  pages={385-93}
}
Osteoblast-like cells isolated from fetal rat calvaria (RC) form three-dimensional nodules in vitro having the morphological and immunohistochemical characteristics of bone. When administered continually over 21 days of culture, EGF caused a dose-related inhibition of nodule formation, as well as a reduction in the proportion of mineralized nodules, at concentrations between 10(-12) to 10(-7) M. The same conditions caused an increase in both cell proliferation and saturation density in the… CONTINUE READING

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