Biphasic effects of cannabinoids on acetylcholine release in the hippocampus: site and mechanism of action.

@article{Tzavara2003BiphasicEO,
  title={Biphasic effects of cannabinoids on acetylcholine release in the hippocampus: site and mechanism of action.},
  author={Eleni Th Tzavara and Mark R. Wade and George G. Nomikos},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 28},
  pages={9374-84}
}
Cannabinoids have been shown to critically modulate cholinergic neurotransmission in the hippocampus, yet opposing effects of cannabinoid receptor 1 (CB1R) agonists on hippocampal synaptic acetylcholine (ACh) efflux have been reported. This study shows that administration of a synthetic CB1R agonist results in a biphasic, dose-dependent, effect on… CONTINUE READING