Biphasic cytochrome c release after transient global ischemia and its inhibition by hypothermia.

@article{Zhao2005BiphasicCC,
  title={Biphasic cytochrome c release after transient global ischemia and its inhibition by hypothermia.},
  author={Heng Zhao and Midori A Yenari and Danye Cheng and Robert Morris Sapolsky and G K Steinberg},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2005},
  volume={25 9},
  pages={
          1119-29
        }
}
Hypothermia is effective in preventing ischemic damage. A caspase-dependent apoptotic pathway is involved in ischemic damage, but how hypothermia inhibits this pathway after global cerebral ischemia has not been well explored. It was determined whether hypothermia protects the brain by altering cytochrome c release and caspase activity. Cerebral ischemia was produced by two-vessel occlusion plus hypotension for 10 mins. Body temperature in hypothermic animals was reduced to 33 degrees C before… CONTINUE READING
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