Biphasic contractile response of pulmonary artery to hypoxia.

  title={Biphasic contractile response of pulmonary artery to hypoxia.},
  author={R E Bennie and C. Subah Packer and Dennis R Powell and Nan Ge Jin and Rodney A. Rhoades},
  journal={The American journal of physiology},
  volume={261 2 Pt 1},
Isolated perfused lungs exposed to low O2 exhibit a hypoxic pulmonary vasoconstriction response that is transient in nature. The purpose of this study was to determine whether the isolated pulmonary artery behaves similarly in response to hypoxia. Rat pulmonary arterial rings were placed in tissue baths (37 degrees C, air-5% CO2, pH = 7.4) and attached to force transducers. Maximum contractile responses (Po) to high K+ were elicited. After washout, arterial rings were submaximally contracted… CONTINUE READING

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