Biphasic concentration change during continuous midazolam administration in brain-injured patients undergoing therapeutic moderate hypothermia.

@article{Fukuoka2004BiphasicCC,
  title={Biphasic concentration change during continuous midazolam administration in brain-injured patients undergoing therapeutic moderate hypothermia.},
  author={Noriyasu Fukuoka and Mayuki Aibiki and Toyohisa Tsukamoto and Keisuke Seki and Shushi Morita},
  journal={Resuscitation},
  year={2004},
  volume={60 2},
  pages={225-30}
}
OBJECTIVE To define the pharmacokinetics of midazolam, a probe for monitoring cytochrome (CYP) 3A 4 activity, during moderate hypothermic therapy. DESIGN A prospective randomized study. SETTING The intensive care unit of a medical university hospital. PATIENTS AND INTERVENTIONS In 15 consecutive brain-injured patients, midazolam concentrations were measured serially using high-performance liquid chromatography (HPLC). Under continuous administration of the agent, eight patients underwent… CONTINUE READING

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