Biphasic changes in mesolimbic dopamine signal during cocaine self-administration.

  title={Biphasic changes in mesolimbic dopamine signal during cocaine self-administration.},
  author={Eugene A Kiyatkin and Elliot A. Stein},
  volume={5 8},
High-speed chronoamperometry with Nafion-coated carbon fiber microelectrodes was used to follow changes in extracellular dopamine (DA) concentration in the nucleus accumbens of rats during intravenous cocaine self-administration (SA) behavior. An abrupt, transient decrease in DA-dependent electrochemical signal was found immediately after cocaine SA, whereas the signal slowly increased preceding each lever-press, reaching a peak at the operant response. Procaine, a local anesthetic, also… CONTINUE READING

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