Biphasic change of progenitor proliferation in dentate gyrus after single dose of isoflurane in young adult rats.

@article{Lin2013BiphasicCO,
  title={Biphasic change of progenitor proliferation in dentate gyrus after single dose of isoflurane in young adult rats.},
  author={Nan Horng Lin and Tiffany S Moon and Greg Stratmann and Jeffrey W. Sall},
  journal={Journal of neurosurgical anesthesiology},
  year={2013},
  volume={25 3},
  pages={
          306-10
        }
}
BACKGROUND Isoflurane exposure causes improvement in long-term neurocognitive function in young adult rats; this is associated with an increase in dentate gyrus (DG) progenitor proliferation 4 days after anesthesia. However, the number of new neurons that were born from cells that incorporated bromodeoxyuridine (BrdU) 4 days after anesthesia is not affected by anesthesia. We tested the hypothesis that progenitor proliferation continues to increase past 4 days, which would imply the possibility… CONTINUE READING
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