Biphasic Respiratory Depression after Fentanyl—Droperidol or Fentanyl Alone Used to Supplement Nitrous Oxide Anesthesia

@article{Becker1976BiphasicRD,
  title={Biphasic Respiratory Depression after Fentanyl—Droperidol or Fentanyl Alone Used to Supplement Nitrous Oxide Anesthesia},
  author={L. Becker and B. Paulson and R. Miller and J. Severinghaus and E. Eger},
  journal={Anesthesiology},
  year={1976},
  volume={44},
  pages={291–295}
}
Either fentanyl or Innovar (fentanyl, 0.05 mg/ml, and droperidol 2.5 mg/ml) was administered to supplement nitrous oxide anesthesia for operations on 29 patients. Both fentanyl and Innovar depressed the slope of the rebreathing CO2 response curve during operation to 42 per cent ± 6 (mean of all intraoperative values, ± SE) of the awake control value. Following the last injection of drug but with continuation of operation, the slope increased such that it was 77 percent r S of control on the… Expand
Antagonism of fentanyl and alfentanil by intravenous plus subcutaneous naloxone
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Twenty patients undergoing microlaryngoscopy were anaesthetised with thiopentone and half received fentanyl supplementation and the other half alfentanil and Respiratory depression in the alfenil group was less pronounced and of shorter duration than in the fentanyl group. Expand
FENTANYL , INNOVAR AND CONTROL OF BREATHING 601
Ventilation ( VI), end-tidal (^002), mixed venous (PVOO£) and the ventilatory response to carbon dioxide were measured before surgery, and during the first 4 h of recovery in 18 adult patients whoExpand
Control of breathing after fentanyl and Innovar anaesthesia.
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Fentanyl and Innovar anaesthesia displaced the carbon dioxide response to the right, but no correlation was found between either the magnitude of the displacement of the response curve or the alteration in slope and the control values, suggesting that patients with a low value of VI/PCO2 are not more susceptible to the ventilatory depressed action of narcotic anaesthetics. Expand
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Whole-body clearance of fentanyl was significantly decreased by hypocapnic hyperventilation, and effects on postoperative ventilation of, two doses of fentanyl administered at the start of general anesthesia in which ventilation was controlled at a fixed volume. Expand
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Nausea and vomiting were more frequent in the fentanyl group, and four of the fentanyl patients required naloxone, and isoflurane appeared to provide a better recovery with less side effects than fentanyl. Expand
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  • D. Robinson
  • Medicine
  • Canadian journal of anaesthesia = Journal canadien d'anesthesie
  • 1988
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The use of moderately high doses of sufentanil as a supplement to anaesthesia could be associated with significant respiratory depression in the early postoperative period, and the cumulation and persistence of fentanyl may cause unexpectedly prolonged ventilatory depression. Expand
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It is concluded that prolonged alfentanil administration may result in severe arterial O2desaturation with significant depression of the hyper-capnic respiratory drive during the first hour in the postanesthesia care unit, even though the majority of patients were easily aroused in response to verbal stimuli. Expand
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Three general surgical patients in whom respiratory distress developed three to five hours following colon surgery when a moderate dose of fentanyl citrate, 55 to 75 micrograms/kg, was used are described. Expand
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From the study, 20 micrograms/kg butorphanol appears to be as suitable as 2 microgramS/kg fentanyl for use as a preinduction narcotic analgesic, whereas 40 microgram/kgbutorphanol seems to be unsuitable due to increased duration of nausea, dizziness, and time to score 10 on APARS and reach discharge-ready status. Expand
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