Biphasic MLL takes helm at cell cycle control: implications in human mixed lineage leukemia.

@article{Liu2008BiphasicMT,
  title={Biphasic MLL takes helm at cell cycle control: implications in human mixed lineage leukemia.},
  author={Han Liu and Shugaku Takeda and Emily H-Y Cheng and James J-D Hsieh},
  journal={Cell cycle},
  year={2008},
  volume={7 4},
  pages={428-35}
}
Discovered in 1992 from cloning the gene involved in human leukemias carrying chromosome band 11q23 translocations, the MLL/HRX/ALL-1 gene has since attracted scientists from various disciplines by its diverse functions in normal physiological and pathological processes. MLL is the human orthologue of Drosophila trithorax (trx)-the founding member of trithorax group proteins, Trx-G. Leukemogenic11q23 translocations fuse the common MLL N-terminal 1400aa in-frame with a wide variety of fusion… CONTINUE READING
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