Biphasic Finite Element Model of Solute Transport for Direct Infusion into Nervous Tissue

@article{Chen2007BiphasicFE,
  title={Biphasic Finite Element Model of Solute Transport for Direct Infusion into Nervous Tissue},
  author={Xiaoming Chen and Malisa Sarntinoranont},
  journal={Annals of Biomedical Engineering},
  year={2007},
  volume={35},
  pages={2145-2158}
}
Infusion-based techniques are promising drug delivery methods for treating diseases of the nervous system. Direct infusion into tissue parenchyma circumvents the blood–brain barrier, localizes delivery, and facilitates transport of macromolecular agents. Computational models that predict interstitial flow and solute transport may aid in protocol design and optimization. We have developed a biphasic finite element (FE) model that accounts for local, flow-induced tissue swelling around an… CONTINUE READING
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