Biphasic Alteration of Butyrylcholinesterase (BChE) During Prostate Cancer Development

  title={Biphasic Alteration of Butyrylcholinesterase (BChE) During Prostate Cancer Development},
  author={Yan Gu and Mathilda Jing Chow and Anil B. Kapoor and Wenjuan Mei and Yanzhi Jiang and Judy Yan and Jason De Melo and Maryam Seliman and Huixiang Yang and J C Cutz and Michael Bonert and Pierre P. Major and Damu Tang},
  booktitle={Translational oncology},
Butyrylcholinesterase (BChE) is a plasma enzyme that hydrolyzes ghrelin and bioactive esters, suggesting a role in modulating metabolism. Serum BChE is reduced in cancer patients. In prostate cancer (PC), the down-regulation is associated with disease recurrence. Nonetheless, how BChE is expressed in PC and its impact on PC remain unclear. We report here the biphasic changes of BChE expression in PC. In vitro, BChE expression was decreased in more tumorigenic PC stem-like cells (PCSLCs), DU145… CONTINUE READING