Biperiden selectively induces memory impairment in healthy volunteers: no interaction with citalopram

@article{Sambeth2014BiperidenSI,
  title={Biperiden selectively induces memory impairment in healthy volunteers: no interaction with citalopram},
  author={Anke Sambeth and Wim J. Riedel and Inge P M Klinkenberg and Seppo K{\"a}hk{\"o}nen and Arjan Blokland},
  journal={Psychopharmacology},
  year={2014},
  volume={232},
  pages={1887-1897}
}
Traditionally, the non-selective muscarinic antagonist scopolamine has been used to induce episodic memory impairments as found in Alzheimer’s disease (AD). However, it also impairs attention and induces drowsiness. Muscarinic antagonists more selective for the M1 receptor might, therefore, be preferred. We examined the effects of the M1 antagonist biperiden on cognitive functions in order to test the specificity of this drug on memory performance. Additionally, we assessed whether the… CONTINUE READING

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Manual for the profile of mood states

  • DM McNair, M Lorr, LF Droppleman
  • 1971
Highly Influential
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