Bipartite structure of the inactive mouse X chromosome

Abstract

In mammals, one of the female X chromosomes and all imprinted genes are expressed exclusively from a single allele in somatic cells. To evaluate structural changes associated with allelic silencing, we have applied a recently developed Hi-C assay that uses DNase I for chromatin fragmentation to mouse F1 hybrid systems. We find radically different… (More)
DOI: 10.1186/s13059-015-0728-8

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