Bipartite structure of the alpha-lactalbumin molten globule.

  title={Bipartite structure of the alpha-lactalbumin molten globule.},
  author={Lawren C. Wu and Zai Yun Peng and Peter S. Kim},
  journal={Nature structural biology},
  volume={2 4},
Molten globules are thought to be general intermediates in protein folding. Apparently conflicting studies have failed to clarify whether one of the best characterized molten globules, that of alpha-lactalbumin, resembles an expanded native-like protein or a nonspecific collapsed polypeptide. Here we show that the molten globule properties of alpha-lactalbumin are largely confined to one of its two domains. The alpha-helical domain forms a helical structure with a native-like tertiary fold… CONTINUE READING

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