Bipartite nuclear localization signals in the C terminus of human topoisomerase II alpha.

@article{Mirski1997BipartiteNL,
  title={Bipartite nuclear localization signals in the C terminus of human topoisomerase II alpha.},
  author={Shelagh E. L. Mirski and James H. Gerlach and H J Cummings and Ralph A. Zirngibl and Peter A. Greer and Susan P. C. Cole},
  journal={Experimental cell research},
  year={1997},
  volume={237 2},
  pages={452-5}
}
DNA topoisomerase II alpha is the intracellular target for several important chemotherapeutic agents, and drug-resistant human tumor cell lines have been described in which deletions in the C-proximal region of this enzyme are associated with its cytoplasmic localization. We have identified multiple potential bipartite nuclear localization signal (NLS) sequences in this region using a modified definition of the motif, and in the present study, we have expressed five of these as fusion proteins… CONTINUE READING