BipA: a tyrosine-phosphorylated GTPase that mediates interactions between enteropathogenic Escherichia coli (EPEC) and epithelial cells.

@article{Farris1998BipAAT,
  title={BipA: a tyrosine-phosphorylated GTPase that mediates interactions between enteropathogenic Escherichia coli (EPEC) and epithelial cells.},
  author={Michele Farris and Andrew A. T. Grant and Tobias B. Richardson and C. David O'Connor},
  journal={Molecular microbiology},
  year={1998},
  volume={28 2},
  pages={265-79}
}
We report the functional characterization of BipA, a GTPase that undergoes tyrosine phosphorylation in an enteropathogenic Escherichia coli (EPEC) strain. BipA mutants adhere to cultured epithelial cells but fail to trigger the characteristic cytoskeletal rearrangements found in cells infected with wild-type EPEC. In contrast, increased expression of BipA enhances actin remodelling and results in the hyperformation of pseudopods. BipA appears to be the first example of a new class of virulence… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

The bacterial translation stress response.

FEMS microbiology reviews • 2014
View 11 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…