• DOI:10.3109/00498259109043212
• Corpus ID: 11003194

Biotransformation study of para-substituted phenylpiperazines in beagle dogs by gas chromatography-mass spectrometry.

@article{Galmier1991BiotransformationSO,
  title={Biotransformation study of para-substituted phenylpiperazines in beagle dogs by gas chromatography-mass spectrometry.},
  author={M. -J. Galmier and J. F. Pognat and C. Lartigue-Mattei and Jean Louis Chabard and Madeleine Bastide and Norbert Busch and J. A. Berger},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1991},
  volume={21 10},
  pages={
          1371-84
        }
}

• M. Galmier, J. Pognat, +4 authors J. Berger
• Published 1991
• Chemistry
• Xenobiotica; the fate of foreign compounds in biological systems

1. Beagle dogs were treated orally (10 mg/kg) with para-chloro-, para-fluoro- and para-methyl-phenylpiperazine derivatives, and urine was collected for 72 h after treatment. 2. Metabolites were extracted, converted into trimethylsilyl (TMS) derivatives and examined by g.l.c.-mass spectrometry. 3. The metabolites fall into two main groups, N-desphenylated metabolites, which result from N-desphenylation, and N-phenyl metabolites. 4. Two kinds of hydroxylated metabolites were found. Some lost the original para substituent (Cl, F or CH3); others retained it. 5. These results are consistent with the NIH shift reaction.