Biotransformation profiling of [(14)C]ixabepilone in human plasma, urine and feces samples using accelerator mass spectrometry (AMS).

@article{mezolu2009BiotransformationPO,
  title={Biotransformation profiling of [(14)C]ixabepilone in human plasma, urine and feces samples using accelerator mass spectrometry (AMS).},
  author={S. Nilg{\"u}n Ç{\"o}mezoğlu and Van Ly and Donglu Zhang and W Griffith Humphreys and Samuel J. Bonacorsi and Donald W. Everett and Marvin B. Cohen and Jinping Gan and Jan Hendrik Beumer and Jos H. Beijnen and Hein Schellens and Graham Lappin},
  journal={Drug metabolism and pharmacokinetics},
  year={2009},
  volume={24 6},
  pages={511-22}
}
Ixabepilone (BMS-247550, Ixempra is a semi-synthetic analog of the natural product epothilone B and marketed for its use in the treatment of cancer. A conventional human ADME study using decay counting methods for (14)C detection could not be conducted due to the radiolytic instability of [(14)C]ixabepilone at a typical specific activity (generally 1-10 microCi/mg). However, [(14)C]ixabepilone was sufficiently stable at low specific activity (1-2 nCi/mg). These low levels required the use of… CONTINUE READING

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