Biotransformation of the sesquiterpene (+)-valencene by cytochrome P450cam and P450BM-3.

  title={Biotransformation of the sesquiterpene (+)-valencene by cytochrome P450cam and P450BM-3.},
  author={Rebecca J. Sowden and Samina Yasmin and Nicholas Huw Rees and Stephen G Bell and L L Wong},
  journal={Organic & biomolecular chemistry},
  volume={3 1},
The sesquiterpenoids are a large class of naturally occurring compounds with biological functions and desirable properties. Oxidation of the sesquiterpene (+)-valencene by wild type and mutants of P450cam from Pseudomonas putida, and of P450BM-3 from Bacillus megaterium, have been investigated as a potential route to (+)-nootkatone, a fine fragrance. Wild type P450cam did not oxidise (+)-valencene but the mutants showed activities up to 9.8 nmol (nmol P450)(-1) min(-1), with (+)-trans-nootkatol… CONTINUE READING

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