Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of Clonostachys sp.

@article{Kakeya2002BiotransformationOT,
  title={Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of Clonostachys sp.},
  author={Hideaki Kakeya and Naoko Takahashi-Ando and Makoto Kimura and Rie Onose and Isamu Yamaguchi and Hiroyuki Osada},
  journal={Bioscience, biotechnology, and biochemistry},
  year={2002},
  volume={66 12},
  pages={2723-6}
}
Zearalenones are mycotoxins with estrogenic activity consisting of a resorcinol moiety fused to a 14-membered macrocyclic lactone and are produced by various Fusarium species. We found that Clonostachys rosea IFO 7063 was effectively capable of converting zearalenone (1) to cleavage product (2), 1-(3,5-dihydroxyphenyl)-10'-hydroxy-1'E-undecene-6'-one. Moreover, cleavage product 2 did not show potent estrogenic activity like that of 1 and 17beta-estradiol in the human breast cancer MCF-7 cell… CONTINUE READING