Biotransformation of sodium nitroprusside into dinitrosyl iron complexes in tissue of ascites tumors of mice.

@article{Kleschyov1994BiotransformationOS,
  title={Biotransformation of sodium nitroprusside into dinitrosyl iron complexes in tissue of ascites tumors of mice.},
  author={Andrei L. Kleschyov and K. R. Sedov and Petr I. Mordvintcev and Anatoly Fjodorovich Vanin},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={202 1},
  pages={168-73}
}
We have found that treatment of various types of murine ascites tumors with sodium nitroprusside (SNP) both in vitro (1.5 mM) and in vivo (25 mg/kg; i.p.) results in formation of EPR-detectable dinitrosyl nonheme iron complexes (DNIC) with RS- groups of proteins (g perpendicular = 2,037; g parallel = 2,012). The DNIC were mainly localized in the ascitic extracellular fluid. The appearance of DNIC was unaffected by an inhibitor of nitric oxide synthase, N omega-nitro-L-arginine (1 mM), but… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-2 of 2 extracted citations

Plant Nitric Oxide

Methods in Molecular Biology • 2016
View 13 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…