Biotransformation of sevoflurane.

@article{Kharasch1995BiotransformationOS,
  title={Biotransformation of sevoflurane.},
  author={E. Kharasch},
  journal={Anesthesia and analgesia},
  year={1995},
  volume={81 6 Suppl},
  pages={
          S27-38
        }
}
  • E. Kharasch
  • Published 1995
  • Medicine
  • Anesthesia and analgesia
  • Several characteristics of sevoflurane biotransformation are apparent from the preceding investigations. Metabolism is rapid, with fluoride and HFIP appearing in plasma within minutes after the start of sevoflurane administration (38-40,51). Peak plasma fluoride concentrations generally occur within approximately 1 h after the termination of sevoflurane administration in most patients, regardless of the dose or duration of exposure (ranging from 0.35-9.5 MAC-h) (39,48). Peak plasma inorganic… CONTINUE READING
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