Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation.

@article{Butler1997BiotransformationOP,
  title={Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation.},
  author={Alison M Butler and Michael Murray},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={280 2},
  pages={966-73}
}
Studies in rat liver have shown that cytochrome P450 (CYP) enzymes mediate the oxidative biotransformation of the phosphorothioate pesticide parathion to paraoxon and 4-nitrophenol. Transfer of the phosphorothioate thionosulfur atom to the CYP apoprotein results in amino acid modification and enzyme inactivation. Our study investigated the role of human hepatic CYP in parathion oxidation and their relative susceptibilities to inhibition and inactivation. Rates of parathion oxidation varied… CONTINUE READING