• Corpus ID: 24017523

Biotransformation of nitrendipine in rat, dog, and mouse.

@article{Scherling1991BiotransformationON,
  title={Biotransformation of nitrendipine in rat, dog, and mouse.},
  author={Dietrich Scherling and Wolfgang Karl and Hans Juergen Ahr and Armin Kern and H. M. Siefert},
  journal={Arzneimittel-Forschung},
  year={1991},
  volume={41 10},
  pages={
          1009-21
        }
}
14C-Labelled Nitrendipine (Bay e 5009; Baypress, Bayotensin; CAS 39562-70-4) was administered by the oral and intraduodenal route to rats, dogs, and mice (oral dosing only) to elucidate the biotransformation pathways in these three species. The drug was extensively metabolized: 20 biotransformation products were identified by comparison with synthetic reference compounds using two-dimensional TLC, HPLC, GC/radio-GC, combined GC/MS (EI-, CI-mode), FAB-MS, and 1H-NMR-spectroscopy. The metabolites… 
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