Biotransformation of moclobemide in humans.

  title={Biotransformation of moclobemide in humans.},
  author={R. Jauch and E Griesser and G. Oesterhelt and Winfried Arnold and W. Meister and Walter H. Ziegler and Theodore W. Guentert},
  journal={Acta psychiatrica Scandinavica. Supplementum},
The structure of the urinary metabolites formed after moclobemide administration in human was elucidated, and the pattern compared with that in the plasma. The metabolic pathways of moclobemide were also compared with those of structurally related substances. After oral moclobemide administration, on average 95% of the dose was recovered in the urine within 4 days, with a mean of 92% being excreted during the first 12 h. The drug is extensively metabolized: less than 1% of the dose was excreted… CONTINUE READING
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