Biotransformation of glycyrrhizin by human intestinal bacteria and its relation to biological activities.

@article{Kim2000BiotransformationOG,
  title={Biotransformation of glycyrrhizin by human intestinal bacteria and its relation to biological activities.},
  author={Do-hoon Kim and Si Won Hong and Bum Tae Kim and E A Bae and H Y Park and Myung Joo Han},
  journal={Archives of pharmacal research},
  year={2000},
  volume={23 2},
  pages={172-7}
}
The relationship between the metabolites of glycyrrhizin (18beta-glycyrrhetinic acid-3-O-beta-D-glucuronopyranosyl-(1-->2)-beta-D-glucuronide, GL) and their biological activities was investigated. By human intestinal microflora, GL was metabolized to 18beta-glycyrrhetinic acid (GA) as a main product and to 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide (GAMG) as a minor product. The former reaction was catalyzed by Eubacterium L-8 and the latter was by Streptococcus LJ-22. Among GL and its… CONTINUE READING

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