Biotransformation of glyceryl trinitrate and isosorbide dinitrate in vascular smooth muscle made tolerant to organic nitrates.

@article{Slack1989BiotransformationOG,
  title={Biotransformation of glyceryl trinitrate and isosorbide dinitrate in vascular smooth muscle made tolerant to organic nitrates.},
  author={C J Slack and Brian E McLaughlin and James F. Brien and Gerald S. Marks and Kanji Nakatsu},
  journal={Canadian journal of physiology and pharmacology},
  year={1989},
  volume={67 11},
  pages={1381-5}
}
It has been proposed that organic nitrates are prodrugs and biotransformation to a pharmacologically active metabolite (i.e., nitric oxide) must occur before the onset of vasodilation. If this postulated mechanism is correct, tolerance to organic nitrate-induced vasodilation might involve decreased biotransformation of organic nitrates by vascular smooth muscle. In this study, biotransformation of isosorbide dinitrate (ISDN) and glyceryl trinitrate (GTN) was estimated by measuring isosorbide… CONTINUE READING