Corpus ID: 23687146

Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells.

@article{Kim2008BiotransformationOG,
  title={Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells.},
  author={Young-suk Kim and Jung-Jin Kim and Ki-ho Cho and Woo-sang Jung and Sang-kwan Moon and Eun-Kyung Park and Dong-Hyun Kim},
  journal={Journal of microbiology and biotechnology},
  year={2008},
  volume={18 6},
  pages={
          1109-14
        }
}
To understand the role of intestinal microflora in the biological effect of functional herbs, which have been used in Korea, Japan, and China as traditional medicines, and suggest new bioactive compounds transformed from herbal constituents, the metabolic activities of the functional herb components (ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, poncirin, hesperidin, glycyrrhizin, and baicalin) toward their bioactive compounds (compound K, crocetin, benzaldehyde… Expand
Metabolic Activities of Ginseng and Its Constituents, Ginsenoside Rb1 and Rg1, by Human Intestinal Microflora
TLDR
Although compound K-forming activity from the aqueous extract of ginseng was low compared to that from ginenoside Rb1, their profiles were similar to those of isolated compounds, and it is believed that the intestinal bacterial metabolic activities of gINSeng components are variable in individuals and may be used as selection markers for responders to ginsENG. Expand
Metabolism of Ginsenosides to Bioactive Compounds by Intestinal Microflora and Its Industrial Application
TLDR
Intestinal microflora play an important role in the pharmacological action of orally administered ginseng, and the activities that metabolize these constituents to bioactive compounds differ significantly between individuals because all individuals possess characteristic indigenous strains of intestinal bacteria. Expand
Effects of broad-spectrum antibiotics on the metabolism and pharmacokinetics of ginsenoside Rb1: a study on rats׳ gut microflora influenced by lincomycin.
TLDR
It is demonstrated that consumption of lincomycin could lead to the formation of specific metabolites and pharmacokinetic changes of ginsenoside Rb1 in the gut, attributed to alterations in metabolic activities of intestinal bacteria. Expand
Metabolism of ginsenoside Rb1 by human intestinal microflora and cloning of its metabolizing β-D-glucosidase from Bifidobacterium longum H-1.
To understand the role of intestinal microflora in expressing the pharmacological effect of ginsenoside Rb1, the metabolic activity of ginsenoside Rb1 by 148 fecal specimens was measured and itsExpand
Enzymatic transformation of ginsenosides in Korean Red Ginseng (Panax ginseng Meyer) extract prepared by Spezyme and Optidex
TLDR
The data showed that the treatments of enzymes including Rapidase are useful for the conversion and increase of ginsenosides in ginseng extracts or products. Expand
Bioactivity and Bioavailability of Ginsenosides are Dependent on the Glycosidase Activities of the A/J Mouse Intestinal Microbiome Defined by Pyrosequencing
TLDR
Conversion to F2 is the rate-limiting step in bioactivation of primary ginsenosides by A/J mouse intestinal microbiome, whose characterization reveals the presence of certain bacterial families capable of enabling the formation of F2 and C-K in vivo. Expand
Comparative Analysis of the Gut Microbiota in People with Different Levels of Ginsenoside Rb1 Degradation to Compound K
TLDR
Intestinal bacterial metabolism of ginseng, particularly ginsenoside Rb1, may be dependent on the composition of gut microbiota, such as Ruminococcus spp. Expand
Metabolism of cyanidin-3-O-beta-D-glucoside isolated from black colored rice and its antiscratching behavioral effect in mice.
TLDR
Findings suggest that C3G-rich BCR may be a beneficial food for diseases involving scratching behaviors, such as chronic dermatitis, rhinitis, and psoriasis. Expand
Characterization of Metabolic Pathways and Absorption of Sea Cucumber Saponins, Holothurin A and Echinoside A, in Vitro and in Vivo.
TLDR
According to the results, deglycosylation is the main intestinal microflora-mediated metabolic pathway for SCSs, and both theSCSs and degly cosylated metabolites can be absorbed by intestine. Expand
The Metabolic Profiling of Isorhamnetin-3-O-Neohesperidoside Produced by Human Intestinal Flora Employing UPLC-Q-TOF/MS.
TLDR
In this study, ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry together with automated data analysis software (Metabolynx™) was used for analysis of the metabolic profile of isorhamnetin-3-O-neohesperidoside by the isolated human intestinal bacteria. Expand
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References

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Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora.
TLDR
The results suggest that the human intestinal microflora enzymes that convert herbal components to their bioactive compounds may be used as selection markers of responders to traditional medicines. Expand
Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect.
TLDR
It is suggested that the ginsenosides Rh1 and/or F1 may not be suitable substrates of intestinal bacteria, particularly Bacteroides JY-6, which showed the greatest estrogenic effect in human breast carcinoma MCF-7 cells. Expand
Metabolism of Ginsenoside Rg5, a Main Constituent Isolated from Red Ginseng, by Human Intestinal Microflora and Their Antiallergic Effect
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Review : Herbal Medicines Are Activated by Intestinal Microflora
TLDR
Glycosides of herbal medicines, such as glycyrrhizin, ginsenosides, kalopanaxsaponins, rutin and ponicirin, were studied regrading their metabolic fates and pharmacological actions in relation to intestinal bacterial using germ-free, gnotobiotic and conventional animals to suggest that glycoside of herbal medicine are prodrugs. Expand
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TLDR
Anti-platelet activity and cytotoxicity of the metabolites of flavonoid glycosides by human intestinal bacteria were more effective than those of the parental compounds. Expand
Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria.
TLDR
Ginsenoside Rb1 and Rb2 were anaerobically incubated with human intestinal microflora and several kinds of intestinal bacteria hydrolyzed these ginsenosides, causing them to be metabolized to 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol (compound K) and 20(S) - protopanxadiol. Expand
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TLDR
The present study demonstrated in vivo and in vitro antimetastatic activities of a major intestinal bacterial metabolite M1 formed from protopanaxadiol saponins of ginseng in comparison with its whole standardized extract and ginsenoside Rb1, Rb2, and Rc. Expand
Transformation of Ginsenosides to compound K(IH-901) by Lactic Acid Bacteria of Human Intestine
TLDR
It is suggested that, if ginseng with these mixed bifidobacteria is fermented, compound K-enforced ginsENG materials could be produced that show cytotoxicity against tumor cell lines. Expand
Fecal metabolic activities of herbal components to bioactive compounds
TLDR
The results suggest that the metabolic activity of herbal components to bioactive compounds may be a factor of constitutional classification, and could be available for constitutional classifications, if the constitutional herbal medicines were used. Expand
Intestinal bacteria activate estrogenic effect of main constituents puerarin and daidzin of Pueraria thunbergiana.
TLDR
It is suggested that intestinal bacteria, which can hydrolyze puerarin and/or daidzin, may activate a potent estrogenic activity of PT. Expand
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