Biotransformation of cyclosporin in primary rat, porcine and human liver cell co-cultures.

Abstract

The purpose of this study was to investigate the species-specific cyclosporin biotransformation in primary rat, human, and porcine liver cell cultures, and to investigate the suitability of a modified sandwich culture technique with non-purified liver cell co-cultures for drug metabolism studies. A sandwich culture was found to enhance hepatocellular… (More)

Topics

Cite this paper

@article{Schmelzer2006BiotransformationOC, title={Biotransformation of cyclosporin in primary rat, porcine and human liver cell co-cultures.}, author={Elmon Schmelzer and Ayla Açikg{\"o}z and Nils Roman Fr{\"u}hauf and Olaf Crome and Jurgen L Klempnauer and Uwe Christians and Angela Maria Bader}, journal={Xenobiotica; the fate of foreign compounds in biological systems}, year={2006}, volume={36 8}, pages={693-708} }