Biotransformation of beta-nortestosterone by cultured porcine hepatocytes.

  title={Biotransformation of beta-nortestosterone by cultured porcine hepatocytes.},
  author={Laurentius A. P. Hoogenboom and M C Berghmans and Wim A Traag},
  journal={Journal of chromatography},
  volume={489 1},
The metabolism of beta-nortestosterone by porcine hepatocytes was investigated. Initially beta-nortestosterone was rapidly oxidized to norandrostenedione, which was further transformed into a number of more hydrophilic compounds. It is assumed that most of these compounds were glucuronides, considering the effect of beta-glucuronidase treatment. The main product of enzymatic cleavage was investigated by gas chromatography-mass spectrometry but could not be identified until now. 

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