Biotransformation of an africanane sesquiterpene by the fungus Mucor plumbeus.

@article{Fraga2017BiotransformationOA,
  title={Biotransformation of an africanane sesquiterpene by the fungus Mucor plumbeus.},
  author={Braulio M. Fraga and Carmen Elisa D{\'i}az and Leonardo J. Amador and Mat{\'i}as Reina and Mat{\'i}as L{\'o}pez-Rodr{\'i}guez and Azucena Gonz{\'a}lez-Coloma},
  journal={Phytochemistry},
  year={2017},
  volume={135},
  pages={
          73-79
        }
}
3 Citations
Sesquiterpene Lactones from Artemisia absinthium. Biotransformation and Rearrangement of the Insect Antifeedant 3α-hydroxypelenolide
TLDR
The major lactone isolated, 3α-hydroxypelenolide, was biotransformed by the fungus Mucor plumbeus affording the corresponding 1β, 10α-epoxide, and showed strong antifeedant effects against Leptinotarsa decemlineata and cytotoxic activity to Sf9 insect cells.
Scalable Syntheses and Biological Evaluation of Africane‐Type Sesquiterpenoids
Practical total syntheses of africane‐type sesquiterpenoids were realized by reexamination of a divergent strategy employing optimized three‐component coupling followed by ring‐closing metathesis and
Biotransformation of sesquiterpenoids: a recent insight
TLDR
A comprehensive summary of biotransformation products of sesquiterpenoids and its structural modification utilizing a variety of biocatalysts including microorganisms, plant tissue culture and enzymes is described.

References

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Biotransformation of the diterpenes epicandicandiol and candicandiol by Mucor plumbeus.
TLDR
The main difference observed in both feedings, resulting from the spatial change in the orientation of the 7-hydroxyl, was the formation of a 3alpha- and a 9beta-Hydroxylated derivative.
Microbiological transformation of manoyl oxide derivatives by Mucor plumbeus.
TLDR
Biotransformations of jhanol, jhanidiol, and 1-oxo-jhanol by the fungus Mucor plumbeus have been studied and hydroxylations observed were at the 2alpha (19), 2beta (20), 3alpha (23), 3beta (24), and 11beta (18) positions.
Antifeedant and Phytotoxic Activity of the Sesquiterpene p-Benzoquinone Perezone and Some of its Derivatives
TLDR
Determination of the phytotoxic activity of 1–5 revealed that 3 had a significant inhibition effect on Lactuca sativa radicle length growth and led to a reduction in antifeedant activity.
Selective Action of Acetogenin Mitochondrial Complex I Inhibitors
TLDR
The in vivo effects of these compounds on S. littoralis and their cytotoxic effects on Sf9 and tumor cells were more predictable than their effect on T. cruzi and mammalian cells.
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